diabetes research

Developing Best Care Practices for Patients with Diabetes Undergoing Surgery

Tamra Dukatz, Certified Registered Nurse Anesthetist

Tamra Dukatz, Certified Registered Nurse Anesthetist

People with diabetes need special care in the surgical setting to control blood sugar. Tammy Dukatz, a certified registered nurse anesthetist at Beaumont Health, has spent a lot of time, with exceptional success, doing research to develop best care practices for patients with diabetes who are undergoing surgery. Tammy has been a nurse anesthetist for more than 25 years and a nurse for 40 years. For the last 15 years, she has taken a great interest in diabetes since two of her three children developed type 1 diabetes. Her research has been aimed at strategies for the best possible glycemic control during surgery. She credits her colleagues and the anesthesia department leadership with phenomenal interest and support for these projects.

Conducting research with endocrinologist Dr. Solomon Rosenblatt and other Beaumont Health staff members, Tammy brought the Hospital guidelines up to date to provide the most appropriate strategies for blood sugar control for people with diabetes having surgery. This is important because high glucose levels during surgery may cause electrolyte imbalances and dehydration, and lows are especially dangerous under anesthesia because signs and symptoms largely can't be observed. The clinical research study on insulin glargine dosing took place from 2005-2008, was published in 2012, and was centered at Beaumont Hospital in Royal Oak, Michigan.

Now Tammy and her team keep up the guidelines up-to-date. It's a constant – reviewing the anesthesia and diabetes literature for current diabetes tech and best practices. Recent updates in diabetes technology have brought up new questions and decisions to be made. For example, a patient’s home continuous glucose monitoring (CGM) is based off interstitial glucose readings. CGM can be used in the hospital to follow the glucose trends, but patients are treated based on lab values using venous blood draws. Expert opinion is being sought to determine if hybrid closed loop insulin pumps should be kept in auto mode or put in manual mode during surgery.

Tammy has been working on her newest project with a team including her daughter, Gwen, who is a student nurse anesthetist at Oakland University. To make it easier for nurses to ensure accuracy, Dr. Rosenblatt and Gwen created an algorithm to guide insulin use after heart surgery. The whole team worked with Beaumont’s IT department to place the algorithm into an electronic calculator. A pilot was performed in one Beaumont department in September of 2018. For further refinement of this algorithm and help with back-end programming, they are soon to be working with the Oakland University College of Computer Science and Engineering. Tammy's son, Carl, has also been involved in the tech end of this project.

If you have diabetes and you're going into a surgery soon, here are some tips to keep in mind:

  1. It does matter how well you are controlling your diabetes before surgery - it can lead to better outcomes.

  2. If you are scheduled for elective surgery and you are not meeting your blood sugar goals, check with your diabetes care physician. Your physician may recommend medication changes to help prepare for the surgery.

  3. Anesthesia prescreening nurses will give you individualized instructions for the day of surgery. These should include what medications to take and how to handle high and low blood sugars before hospital arrival.

  4. Communicate well with your anesthesia team. Your blood sugar will be checked frequently throughout your surgery and recovery time. Because of the stress of surgery, treatment with insulin is common - even if you do not usually take insulin. Be sure to speak up if you feel that your blood sugar may be low.

In the News: Newly Discovered Hybrid Immune Cell Could Finally Explain The Cause of Type 1 Diabetes

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We have learned that type 1 diabetes is caused by the body's immune system turning against insulin-producing cells. New research has found a 'hybrid' white blood cell that displays features of two of our immune's system most important cells (T and B cells). Further research will work to confirm the white blood cell's actions and possibly provide insight into treatments for diabetes and other immune conditions.

Read the whole article for a lot more details at Science Alert.

Research Underway to Create a Cannula with Lower Risk of Infection & Inflammation

A professor at the University of Central Florida, Elizabeth Brisbois, is working to develop a cannula that can be left in place for as long as 30 days while effectively delivering insulin into the body. Cannulas are small tubes that are inserted beneath the skin to deliver insulin into the body as part of an insulin pump system. The cannula can either be part of the infusion set or attached to the actual insulin pump. Normally, over time, the body’s immune system attacks the cannula, with cells creating a film around the cannula that begins to inhibit proper insulin delivery. That is why infusion sets normally need to be changed every two to three days to reduce the risk of infection. 

Brisbois’ goal is to create cannulas that have a lower risk of infection and inflammation, with reduced pain and inconvenience for patients. She and her team are developing cannulas that release nitric oxide, a molecule that can kill bacteria. Nitric oxide is also produced in the body to fight off germs and has an important role in wound healing.

This advance could significantly increase quality of life for people living with type 1 and type 2 diabetes. Brisbois and her team are funded by a recent grant from the JDRF and are collaborating with researchers at the University of Georgia. Learn more about the cannula research here.

Yale Researchers Work Toward New Treatment for Type 2

Topological map of a toxic pore formed by hundreds of copies of the hormone IAPP.

Topological map of a toxic pore formed by hundreds of copies of the hormone IAPP.

Andrew Miranker and his team have focused their recent studies on a simple hormone in all of us – islet amyloid polypeptide (IAPP). Certain forms of this hormone actually poke toxic holes in cells, and this Yale team is leveraging this information to create new therapies to treat type 2 diabetes.

The progression of type 2 diabetes is tied to the health of insulin-producing cells in the islets, which are groups of cells in the pancreas. These cells are responsible for coordinating the release of insulin in response to changes in blood glucose. The failure of the islets over time plays an important role in the cause of type 2 diabetes as the body loses the ability to regulate blood glucose. Currently, there are no approved drugs available to treat the actual causes of type 2 diabetes.

Miranker’s lab is working with islet amyloid polypeptide (IAPP), a protein partner to insulin. This hormone is made by the same cells as insulin. When IAPP takes on the wrong shape, it pokes holes in the membranes of islets…holes that are large enough to kill these insulin-secreting cells. The Yale team is working hard to design a compound to target the particular, destructive IAPP structure in order to prevent toxicity.

IAPP works alone in its healthy state, but the toxic version is made up of tens to hundreds of copies of the protein.  This creates a widely sprawling structure, and controlling it requires a different approach from those of traditional drugs. A great visual, Miranker’s team is designing a drug that acts like a fork for the spaghetti-like structure of IAPP to wrap around. The Miranker lab has developed a drug lead, ADM-116, that binds to IAPP by crossing the outer cell membrane, finding IAPP, and winding it up. By doing this, ADM-116 prevents IAPP from punching a hole in a sensitive internal cell membrane. This process essentially rescues cells that make insulin.

Using these discoveries, Miranker and his team, and the new Connecticut-based biotechnology company, ADM Therapeutics, will translate these discoveries into drugs that improve the long-term health of these cells. Although this research is currently focused on type 2 diabetes, these approaches will also apply to Alzheimer’s and Parkinson’s diseases.

Learn more from the YaleNews article, “Taming an unruly target in diabetes.” 

New Research: Lack of Sleep Tied to Higher Risk of Diabetes in Kids

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A recent UK study suggests that children who don’t get enough sleep are more likely to develop type 2 diabetes than kids who typically sleep longer. Each additional hour of sleep children get at night is associated with lower body weight, more lean muscle mass, and less accumulation of sugars in the blood. Since obesity and high blood sugars are contributing factors to developing type 2 diabetes, you can see the possible correlation.

This study, based on 4,525 children ages 9 or 10, found that kids who slept less were more likely to be extremely overweight or obese and have more body fat. Children who got less sleep on average per night were also more likely to have a risk factor called insulin resistance, where their bodies don’t respond normally to insulin. An additional factor, insufficient sleep also affects the level of hormones that control appetite, making kids hungrier and increasing cravings for sweet and salty snacks.

The American Academy of Pediatrics suggests that children ages 6 to 12 should get 9 to 12 hours of sleep each night. “Getting enough sleep helps keep our appetite in check and is protective against insulin resistance,” said James Gangwisch, a psychiatry researcher at Columbia University who wasn’t involved in the study.

Read the entire Reuters article.

This Amazing Researcher Is Creating the Smart Patch - It Uses Microneedles to Release Insulin

Check out this article in Diabetes Forecast featuring Zhen Gu, biomedical engineer and researcher, who is reducing the need for needles in diabetes care. He is creating a “smart patch” which uses microneedles to release insulin in tune with the body’s needs. Amazing!

Zhen Gu, researcher from University of North Carolina

Zhen Gu, researcher from University of North Carolina